Henderson is a home rule-class city along the Ohio River in Henderson County in western Kentucky in the United States. The population was 28,757 at the 2010 U.S. census. It is part of the Evansville Metropolitan Area, locally known as the "Kentuckiana" or the "Tri-State Area".Notable residents have included the ornithologist, naturalist, and painter John James Audubon and blues legend W. C. Handy. For more than 100 years the city has been home to the Southern Cherokee Nation.